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2014 Phase II trial (117 bowel surgery patients, NCT00672074), ipamorelin given as 0.03 mg/kg IV twice daily for up to 7 days produced treatment-related adverse event rates similar to placebo

Such phosphorylation might affect proteins like voltage-dependent calcium channels on pituitary cell membranes, possibly resulting in channel opening, calcium influx, and subsequent release of growth hormone from secretory vesicles