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In individuals with IBD, proinflammatory cytokines downregulate OCTN2 through the PPAR/RXR pathway, resulting in reduced carnitine uptake by intestinal epithelial cells that leads to the dysfunction of intestinal regeneration and repair and further deterioration of IBD [232]

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Application of BSO-OxMal , BSO-OxOAc or oxaliplatin significantly reduced tumor volumes as compared to solvent controls during the first two weeks of treatment without significant differences between the three metal drugs (Fig