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The study emphasizes that specific PKC isozymes, triggered by lipid metabolites and hyperglycemia, contribute to vascular abnormalities such as fibrosis, dysfunction of endothelial and vascular smooth muscle cells (VSMC), monocyte activation, cytokine imbalance, excessive extracellular ROS production, and impaired vascular insulin signaling that contribute significantly to DM associated vascular dysfunction [48]

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Chen Z., Zhong C

Eryptosis is characterized by the exposure of PS on the membranes of RBCs, facilitating their clearance from circulation and contributing to anemia in both treated and untreated LC patients

144 A large body of evidence indicates that any type and amount of physical activity is better than none when it comes to cognitive health