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Conceptual schematic illustrating the attenuation of circadian rhythm amplitude and phase shifts in aging, with a particular emphasis on nocturnal melatonin decline as a central driver of sleep fragmentation, metabolic dysregulation, and reduced antioxidant capacity ( The figure highlights age-related changes in key physiological variables, including restactivity cycles, core body temperature, hormonal secretion (melatonin and cortisol), suprachiasmatic nucleus (SCN) neuronal activity, and metabolic indicators such as glucose regulation

Therefore, targeting the HOTAIR/UPF1/ACSL4 axis is an effective strategy to inhibit ferroptosis and reduce neuronal death in ICH (Jin et al., 2021)

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26) and the reaction rate was then measured by monitoring the NADH consumption rate at 340 nm