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Description

This mechanism is particularly vital for patients with mast cell activation syndrome (MCAS) and Long COVID, where the immune system is locked in a state of chronic, inappropriate reactivity

SIRT1 activation restores autophagy by deacetylating FOXO3a and upregulating autophagy-related genes, including Atg5 and LC3-II, enhancing cellular stress adaptability and improving insulin sensitivity

Care 16 , 339345 (2013)

Oxidative stress and chronic inflammation further exacerbate this metabolic disorder, impairing lactate dehydrogenase B (LDHB) function in pancreatic -cells