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Ying et al., 2024)

doi: 10.1186/s12967-025-06925-1

Gold KA, Lee JJ, Ping Y, Behrens C, Liu D, Lee HY, Koo JS, Lotan R Solis L, Rinsurongkawong W, Stewart DJ, Hofstetter WL, Swisher SG , Lippman SM, Wistuba II, Hong WK, Kim ES

Varoglutamstat ( 17 , formerly PQ912), the first small molecule glutaminyl cyclase inhibitor to enter phase II clinical trials, targets an enzyme that catalyzes the conversion of glutamate to pyroglutamate at the N-terminus of A