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PMID: 27406108, PMCID: PMC4961517, DOI: 10.1161/strokeaha.116.012966

Design and expression of peptide antibiotic hPAB- as tandem multimers in Escherichia coli

The majority of ROS (~90%) come from mitochondrial activity during OXPHOS where electrons can escape the inner mitochondrial membrane to generate free radicals, oxygen molecules with highly reactive unpaired electrons