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Integrating multi-omics data, a pathway analysis, and computational modeling may offer powerful tools to investigate metabolic reprogramming in ECs during aging and atherosclerosis, as exemplified by Kalucka et al.s single-cell RNA-sequencing (scRNA-Seq) atlas of 11 mouse tissues, which revealed 78 EC subclusters and highlighted tissue origin as the primary determinant of EC heterogeneity, including tissue-specific metabolic profiles [234]

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3.3 Ferroptosis in IE related diseases In addition to -thal, IE also happens to be present in various hematological disorders, including congenital dyserythropoietic anemia, hereditary sideroblastic anemia, and anemia in acquired conditions such myelodysplastic syndrome (MDS) ( X-linked sideroblastic anemia is a disease in which mutations in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene cause excess iron accumulation and, IE