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The patent dance patent lists, published since 2021, provide structured intelligence on which patents the reference product sponsor considers most defensible, but those lists are reactive, applicant-specific, and not updated proactively after the initial exchange

These include: Neurological symptoms : tingling or numbness in hands and feet (peripheral neuropathy), difficulty walking or balance problems, memory difficulties, or mood changes including depression Haematological signs : persistent fatigue, weakness, pale or jaundiced skin, or shortness of breath Glossitis : a sore, red, smooth tongue Cognitive symptoms : difficulty concentrating, confusion, or "brain fog" Seek urgent medical attention if you experience rapidly worsening neurological symptoms, significant difficulty walking, severe paraesthesia, or marked cognitive decline, as these may require immediate assessment

Considering this, viral infections, particularly by enteroviruses, have also been implicated as a potential environmental trigger for T1D ( Figures 1 , 2 ) ( Enterovirus infection has been associated with T1D for decades (134)

PM & R 12 , 11341139 (2020)