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For initial testing, if patients are on binders, these can be with-held

These systems encapsulate both hydrophilic and lipophilic drug molecules, improving solubility, absorption, and delivery efficacy across biological barriers

J Cereb Blood Flow Metab 32:456467 Urushitani M, Sik A, Sakurai T et al (2006) Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis