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Changes in oxygen consumption (energy expenditure) during food restriction were then reported as percentage of the values obtained from baseline (typically 2 to 3 days of recordings before food restriction)

-Carotene increases protein expression of nuclear NRF2 and upregulates downstream targets containing antioxidant response elements (ARE) such as NADPH quinone oxidoreductase 1 (NQO1) and haeme oxygenase-1 (HO-1), thereby reducing oxidative damage to neurons 142

This provides a more sustained level of the compound for research into more acute conditions, like repairing a damaged gut lining or addressing systemic inflammation

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