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The brain can influence the structure and function of the gut microbiome through the autonomic nervous system (ANS), by regulating local intestinal movement, transport and secretion, and permeability ( Nervous system pathway Stress directly stimulates the chromaffin cells in the medulla through sympathetic nerves to release norepinephrine (NA) and activates neurons in the myenteric plexus 2-adrenergic receptors (ARs), resulting in 2-AR mediated inhibition of intestinal motility through presynaptic and postsynaptic signaling mechanisms ( + ions, which further increases the absorption of water from the intestinal cavity

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