24 Copper homeostasis is tightly regulated in cells To maintain Cu homeostasis at the cellular level, intracellular Cu content is regulated by a complex network of Cu-dependent proteins, including cuproenzymes, Cu chaperones, and membrane transporters
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Stier, H., Vos, E., & Kenley, D
Vitamin B12 deficiency recovery can take time, six to twelve months, but with ongoing supplements, improvement should be gradual