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Notably, the acetylation of histones plays a role in the regulation of gene expression by facilitating transcription (i.e., mRNA synthesis), while deacetylated histones are usually associated with chromatin compaction and gene silencing

At tumoricidal concentrations, RSL3 exhibits cytotoxicity toward normal cellsincluding neurons, fibroblasts, and nephrocytesand demonstrates poor selectivity and pharmacokinetic properties because its reactive alkyl chloride group forms a covalent bond with GPX4 (192)

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10.1079/bjn20061817 114 RuffinM.BrochieroE