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I recommend checking B12 status annually through blood tests specifically serum B12, methylmalonic acid, and homocysteine for a complete picture. Vitamin B12 During Pregnancy Pregnant women need 2.6 mcg of B12 per day slightly more than the standard adult requirement because B12 is actively transferred to the fetus and is critical for fetal brain and nervous system development

When the NNMT enzyme is overactive, its often associated with insulin resistance, a condition where your cells dont respond well to insulin and cant easily take up glucose from your blood

This causes more pain and can reduce the function of your knee

Anjos et al