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These molecular subtypes not only highlight the heterogeneity of GBM but also provide potential targets for precision medicine

Also, itaconate is increasingly produced by macrophages with a disrupted TCA cycle - as shown upon LPS stimulation (Strelko et al., 2011) - but triggers subsequently protective effects, e.g., by the inhibition of succinate dehydrogenase (which controls levels of pro-inflammatory succinate), glycolysis and pro-inflammatory NLRP3 inflammasome activation (Strelko et al., 2011), whereas activating the anti-inflammatory transcription factors NRF2 and ATF3 (Peace and ONeill, 2022)

Zeevalk GD, Manzino L, Sonsalla PK, Bernard LP

et al., 2019), and kudzu polysaccharides may treat diabetes by modulating the PPAR signaling pathway and the structure of intestinal flora (Wang et al., 2022)