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135 On December 18, 2020, B.1.351 was designated as VOC by WHO and named Beta ( Similar to the Alpha variant, B.1.351 lineage also included three subtypes 501Y.V2-1/-2/-3, and 501.Y.V2-1 occupied mainstream, then the 501Y.V2-2 with additional mutations of amino acid site 18 and 417 appeared, and finally Del241/243 mutation occurred in 501Y.V2-3

Axons require the NADase activity of the full length SARM1 to facilitate axonal degeneration and NAD + consumption after injury