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Several randomized placebo-controlled trials on rhGH-replacement therapy in children and adults showed significant increases in serum calcium and urinary calcium concentrations in rhGH-treated patients

In other instances, swelling is the cause of carpal tunnel syndrome

(1992) described the IGF-1 LR3 analog and documented its dramatically reduced IGFBP binding compared to native IGF-1, establishing the pharmacokinetic rationale for its use as a research tool (PMID 1601853)