foxo4-dri senolytic or senomorphic

foxo4-dri senolytic or senomorphic induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation The disordered p53 transactivation domain

Name: foxo4-dri senolytic or senomorphic induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation The disordered p53 transactivation domain
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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications Targeting cellular senescence with senotherapeutics: senolytics and senomorphics Zhang 2023 The FEBS Journal Wiley Online Library Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells eBioMedicine

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Description

Pharmacol Rev 67:564600

Researchers and healthcare professionals utilize peptide-based compounds to explore their potential effects on cellular communication, recovery processes, inflammation modulation, and overall physiological function