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(iii) The linear exchange function slope

10.1016/j.freeradbiomed.2018.09.043 66 HouW.XieY.SongX.SunX.LotzeM

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Pharmacokinetic data from the trial suggested that administering carboplatin before olaparib may be the preferred treatment schedule to enhance the overall clinical benefit of this combination therapy, as pre-exposure to carboplatin causes intracellular accumulation of olaparib ( P = 0.013), thereby improving its effective availability within tumour cells