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For example, the effects of ESI1 may need to be modulated by adjusting the dose, treatment duration, or using pulsed therapy during specific time windows

Gastroenterology 106 , 840845 (1994)

BPC-157 modulates inflammatory responses through the erg-1 transcription factor pathway

Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells