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ROS cause oxidative damage to various cellular components and disrupt the balance between ECM catabolism and anabolism 119

5.1 Preventive antioxidants ROS such as OH, O2, and H 2 O 2 are generated irreversibly during the process of metabolism

A 2023 study published in Nature Metabolism found that vitamin B12 plays a pivotal role in one-carbon metabolism and cellular processes at the mitochondrial level, with B12 availability influencing how efficiently cells carry out energy-related reprogramming