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Although studies directly investigating the effects of PQQ on microbiota composition or function are sparse, a current supposition is that some gut bacteria may require PQQ for optimal function

It can also obscure the fact that there is no validated human use, dose, safety profile or approved indication

[4] Moreover, research points to a possible interaction between DSIP and opioid receptors in the brain, which may play a role in the peptides ability to regulate sleep and mitigate withdrawal symptoms, underscoring its intricate role in neural signaling pathways

2 Recently, microbiota-directed food invention, which was developed to exert therapeutic effects through the manipulation of gut microbiota components, was found to be an effective dietary supplementation strategy for undernourished children