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It tells the pituitary to release GH, which then triggers IGF-1 production and all the downstream effects: muscle repair, fat burning, tissue recovery, and better sleep

10.1007/s00018-016-2203-4 Cell Mol Life Sci

For example, drug development targeting the repair of intestinal barrier function can promote the proliferation and differentiation of intestinal epithelial cells and increase the expression of intercellular tight junction proteins to fundamentally improve intestinal barrier function and reduce the occurrence of inflammation

As for Th9 cells, there is a review that has shown that SIRT1 and HIF1 modulate both Th9 differentiation and ROS generation