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10.1136/bmj-2022-071609 112

But when excessive breast tissue is removed the inward retraction of the nipple-areolar complex becomes more obvious and pronounced as postoperative healing occurs

Mechanistically, BHB enhances BDNF expression in the hippocampus of mice through epigenetic modulation, including inhibition of class I histone deacetylases, and through activation of CREB (cyclic adenosine monophosphate (cAMP) response element-binding protein)-dependent transcriptional pathways [59]