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For an illustrated summary of this Primer, visit: This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 1 digital issues and online access to articles 115,66 per year only 115,66 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

The free tripeptide was first identified in human plasma in 1973 by Loren Pickart as a factor supporting cell proliferation in liver cell cultures, and the copper-binding role of the peptide was recognized shortly afterward as the molecular basis for many of the activities attributed to GHK

Therefore, it can be recommended that the following investigations be conducted whenever fresh/high-quality evidence emerges on the same issue

They make clinical sense when managing documented metabolic adaptation, addressing specific complaints of profound fatigue on GLP-1s, or when gastrointestinal side effects prevent the use of standard therapies