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Genetic and Metabolic Targeting: The development of cell-specific ferroptosis loss-of-function models (e.g., epithelial- or immune-specific GPX4 or ACSL4 knockout systems) will enable precise dissection of compartment-specific contributions to inflammation and metabolic dysregulation

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When patients present with concurrent HPG axis dysfunction, the use of SERMs (e.g., Clomiphene) or aromatase inhibitors (e.g., Anastrozole) can elevate serum testosterone and potentially improve semen parameters