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We have previously demonstrated that forskolin improves mitochondrial oxidative status in frataxin-deficient cells (17) and show here that exenatide alleviates oxidative stress in FRDA patients iPSC-derived sensory neurons (Figure 5)

10.1007/s00432-016-2259-4 J Cancer Res Clin Oncol

Although IGF-IR promotes EMT, it does not necessarily mean that inhibition of IGF-IR is able to reverse this phenotype, due to the compensation by other RTKs