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Stocchi, V., Cucchiarini, L., Canestrari, F., Piacentini, M

Conventional treatments (compression, sclerotherapy, ablation, surgery) manage hemodynamic dysfunction by reducing venous reflux or removing damaged veins entirely they dont restore vein wall collagen, repair endothelial damage, or reverse the cellular pathology that caused varicose veins

Rhee H, Love T, Groth SW, Annette G, Tumiel-Berhalter L, Harrington D The Journal of asthma : official journal of the Association for the Care of Asthma

9 Current experience has found that there is high risk of recurrence with use of the same TNF alpha agent, and about a 50% recurrence rate if using another drug in the same class