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Ethics approval All animal studies were approved by the Institutional Animal Care and Use Committee of Augusta University (Animal Use Protocol #20170868) and were conducted in accordance with the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals

In addition, derivatization and conjugation strategies (such as cyclodextrins and trehalose) have been employed to enhance the stability of carnosine against carnosinase-mediated degradation as well as its pharmacological activity (30)

Both the low expression of Keap1 and the overexpression of Nrf2 led to a significant increase in xCT mRNA levels (up to a 5-fold increase), which subsequently reduced ROS formation

Cardiovascularendocrinemetabolic medicine: proposing a new clinical sub-specialty amid the cardiometabolic pandemic