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Melatonin has also been reported to inhibit the expression of TGF-1, collagen I and SMAD3 phosphorylation in pulmonary cells exposed to cigarette smoke and LPS (Shin et al., 2017)

CtDNA has also emerged as a non-invasive tool to detect minimal residual disease and early detection of recurrence in early stage non-small cell lung cancer (NSCLC) (Tan et al., 2024)