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At the 1500 mg/kg dose, at 48 h, rats exhibited rises in circulating liver enzymes, showing a peak serum alanine aminotransferase (ALT) rise 36-fold above vehicle controls and a 33-fold serum aspartate aminotransferase (AST) rise over control (Fig

In 3-6 hpi ring-stage resistant parasites, we demonstrated lower levels of hemoglobin-derived heme, which is the crucial activator of artemisinin in parasites