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24 Besides, NADPH acts as the reducing reagent for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway, which leads to the synthesis of cholesterol and nonsterol isoprenoids

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This implies that the role of GGT in inducing capacity of GSH to release cysteine, rather than GSH itself, modulates the mTORC1 pathway, ISR and ferroptosis