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doi:10.1097/SAP.0000000000001326 Locketz GD, Bloom JD

MPO plays an important role in inflammation and tissue damage (Lewis and Trempe 2017)

Moreover, the hierarchical model proposed here, whereby NO functions as an upstream triggering signal and lipid peroxidation and mitochondrial ROS constitutes the downstream execution events, should not be interpreted as a strictly linear or universal sequence equally applicable to all cell types or ferroptosis inducers