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A two-codon partitioning model (SRD06 model) 104 , HKY + 4 nucleotide substitution model, and an uncorrelated lognormal relaxed molecular clock (UCLD) with a Bayesian skyline plot (BSP) coalescent tree prior were selected for the Bayesian analysis

Graphical Abstract 1 Introduction 1.1 Vascular cognitive impairment and the public health burden Vascular cognitive impairment (VCI) encompasses the full spectrum of cognitive dysfunction attributable to cerebrovascular disease (CVD) or the presence of vascular risk factors ( VaD, recognized as the second most common form of dementia following Alzheimers disease (AD), exhibits varying prevalence across different regions

Above homogenates were then used for centrifugation at 1000 g for 8 min at 4 C

However, taking supplements with a small amount of food may reduce potential stomach sensitivity in some individuals