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Vascular endothelium injuries are known to precede the development of and to be an essential prerequisite for gross organ injuries

In contrast, several studies suggested that the activation of ERK and JNK phosphorylates MITF at Ser 73 , which leads to its ubiquitination and degradation, thus subsequently down-regulating melanogenesis (not shown in Figure 3) [26,3941]

Written consent was obtained from all patients or their relatives, and the study was approved by the Institutional Research Ethics Committee of the Institutes of Biomedical Sciences, Fudan University

London: National Institute for Health and Care Excellence (NICE)