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Phase 1 Estrogen Ratios Why Should Providers Evaluate 2OH/4OH and 2OH/16OH Ratios to Understand Estrogen Detox

10.1080/10807039891284956 87 LoughJ

An increased kynurenine/tryptophan (Kyn/Trp) ratio correlates with disease The kynurenine pathway is a major route of tryptophan metabolism in humans, in which the enzyme indoleamine 2,3-dioxygenase ( IDO1 ) converts tryptophan to kynurenine via the intermediate N-formyl L-kynurenine, followed by deformylation mediated by arylformamidase [58,59,60], for a schematic illustration, see Fig