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Additionally, though other routes of administration were associated with a modest reduction in heart failure risk, high dose injectable estrogen therapy (defined by the study as 1.45x above standard dose of 10-20mg every 4 weeks) was instead associated with an increased risk

There is no standardized human protocol, so a physician should set your dose based on your condition, body weight, route, and goals

As mitochondrial dysfunction is linked to antifungal resistance in several fungi, similar epimutations likely contribute to development of resistance in fungal pathogens