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Warnings : cocaine toxicity can cause patients to become aggressive, & combative the role of lidocaine in treating ventricular arrhythmias is unclear (there are concerns with it's use due to the fact that it is a Na channel blocker - like cocaine, and may worsen cardiac conduction disturbances or induce seizures) non-selective beta blockers should be avoided (due to concern about creating unopposed alpha-adrenergic mediated coronary vasoconstriction in the presence of elevated catecholamines, with blockade of beta-2 receptors) in the absence of serious toxic reactions, the (non-lethal) acute effects of cocaine are generally short-lived due to its short half life (~50 mins) although this may be prolonged 2-3 fold if alcohol is co-ingested (due to the formation of cocaethylene , which has a longer half life) References: Olson KR (2007): Poisoning & Drug Overdose