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126 Interestingly, inhibition of GADPH and PKM2 redirects glucose-6-phosphate (G6P) flux away from glycolysis and towards the oxidative arm of the PPP, which produces NADPH, thereby boosting NADPH production to counter oxidative stress

It is unusual, especially among individuals of northern European extraction, to observe familial occurrence of primary AS when there is no familial occurrence of HLA-B27, UC, CD and psoriasis

However, determining the stability of cognitive performance requires long follow-up periods, ideally with multiple data collection points, which is often not feasible

Surprisingly, the interaction of Cu ions with HD crystallin also promotes protein folding [53]