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17 Under hypoxic conditions, a decrease in hydroxylation results in a reduction in the synthesis of the VHL and HIF-1 complex, which in turn promotes the stable production of HIF-1

Methotrexate is an antimetabolite used in treatment of cancer, autoimmune diseases and induction of abortion

Patients with diabetes or hypertension may have altered iron homeostasis and oxidative stress profiles, which could influence the effectiveness of ferroptosis-targeted therapies (He et al