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Notably, SIRT1 functions as a sensor of redox changes and plays a critical protective role against ferroptosis by regulating redox homeostasis via Nuclear factor erythroid 2-related factor 2 (Nrf2) and p53 ( 2.1.1 Role of SIRT1- Nrf2 in ferroptosis Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that maintains redox balance and protects cells from oxidative damage