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Notably, post-mortem studies revealed reduced activity of respiratory chain complexes in a group of ASD children, suggesting that abnormalities, especially in the frontal, temporal and cerebellar areas (Tang et al., 2013), may cause mitochondrial impairment and contribute to the appearance of the first symptoms (Siddiqui et al., 2016)

Regarding the secondary endpoints, we did not obtain significant results in self-sufficiency and FVC with both ALCAR 3 g/day and 1.5 g/day

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