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More studies should be conducted to investigate whether the observed increases in cytokines IFN-, TNF-, IL-2, and decrease in IL-10 found in granuloma supernatants is indeed the cause of the decreased burden of mycobacterial

They can be loaded with chemotherapeutic agents, gene therapy vectors, or photothermal and photodynamic therapy (PDT) agents, effectively inducing tumor cell destruction

Alternatively, PZA can be initially oxidized to 5-hydroxy-pyrazinamide (5-OH-PZA) by XO, followed by amidase-mediated hydrolysis to 5-OH-PA

[12] These metabolites have approximately 30 to 100 times greater affinity for the ERs than tamoxifen itself