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doi: 10.1016/j.celrep.2016.09.008 22 MacIverNJMichalekRDRathmellJC

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For example, the 5-year survival rate for the most common clear cell RCC after metastasis is 30 genes have been reported to be abnormally hypermethylated in prostate cancer, including genes involved in hormonal response, cell cycle regulation, cell invasion and DNA damage repair

vascular endothelial growth factor (VEGF) and angiopoietin-1, leading to the induction of genes involved in angiogenesis and thus represent therapeutic targets for the inhibition of tumor angiogenesis [122]