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Aquilariae Lignum fraction pretreatment of LPS-stimulated BV2 microglia cells significantly reduced NO, cyclooxygenase-2 (COX-2), IL-1, and prostaglandin E2 levels and attenuated nuclear factor-kappaB (NF-B) and p65 activities [109]

Acyl-CoA synthetase long-chain family member 4 (ACSL4) thioesterifies arachidonic acid (AA) or adrenic acid (ADA) in PUFA-related phospholipids into PUFACoA [47], which is then esterified by lysophosphatidylcholine acyltransferase 3 (LPCAT3) into phospholipid polyunsaturated fatty acids (PUFAPL) [48]

In our study, we analyzed the single-cell RNA-Seq (scRNA-Seq) data from cervical draining lymph nodes (CDLNs) of mice with experimental autoimmune uveitis (EAU), revealing an increased abundance of fatty acids in Th17 cells

Face cette surproduction de radicaux libres , les mcanismes de dfenses naturelles sont bien souvent dpasss et sinstalle alors un stress oxydant ou stress oxydatif