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The headline belongs at the top, not buried under the neurogenesis story: NSI-189's Phase 2 trial failed its primary endpoint for depression, and clinical development was discontinued

In preclinical models, GIP receptor agonism attenuates emesis while increasing the amount of body weight reduction in comparison to GLP- 1 agonism alone [148]

This is not surprising because the combined fingerprint data set allows the most informative features of any binary fingerprint to be used in the model

The disconnect between short plasma half-life and prolonged therapeutic effects observed in many studies supports tissue-level mechanisms extending beyond circulating peptide concentrations