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A few commenters encouraged CMS to increase the weight of the Safety of Care domain within the existing methodology (for example, from 22 percent to 30 percent) while reducing the weight of other domains proportionally, allowing safety to have a greater influence on the Overall Hospital Quality Star Rating without introducing categorical penalties

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monitoring recommended in polypharmacy settings NAD+ has the clear safety advantage through human trial data across diverse populations, though long-term safety remains unestablished for both interventions

Researchers study it