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In DCs, lipids act as second messengers and effectors, playing a critical role in cell differentiation and the regulation of important immune functions [130]

Collectively, these changes translate into a more pronounced improvement in mucosal barrier repair than that achieved with 5-ASA alone ( The combination of natural bioactive compounds with 5-ASA offers a novel therapeutic strategy for ulcerative colitis through a stage-specific, multi-target synergistic approach.These complementary mechanismsspanning acute immunomodulation, antioxidative damage, followed by active mucosal repair, and microbiota-metabolic regulationare visually integrated in Figure 2, which provides a comprehensive overview of their temporally coordinated actions

2 University of Colombo, Colombo 8, Sri Lanka

Herbal nanomedicines: recent advancements, challenges, opportunities and regulatory overview