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It is worth noting that the anticancer and immunomodulatory role of bilirubin in nanomedicines was overlooked in some of the above experiments, which focused on its high photothermal conversion efficiency as a photosensitizer on tumors, without noting that the anticancer role of bilirubin/biliverdin as a ROS scavenger in its own right should not be underestimated

The ionic strength and polarity of the solvent can have a minor impact on the pK a of a buffer solution

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